Bioabsorbable Polymers: PGLA and PolyDioxanone (PDO) as Workhorse Materials for Device Development
Continuing the evolution of the bioresorbable medical device market has led to significant growth of the implantable device industry. When considering a bioabsorbable polymer to use for your specific device, many criteria should be considered based on the design requirements and desired functionality of the device’s intended use. Two (2) workhorse polymers that have endured the demand of multiple devices would be our Max-Prene® 955 and Dioxaprene® 100M. These polyester-based polymers have demonstrated their ability to support the need for the most demanding applications through their unique material properties.
Max-Prene® 955 is a fast-degrading, high strength, high stiffness polymer mainly comprised of glycolide with minor segments of L-lactide. Attributable to its high glycolide content, Max-Prene® 955 allows for a faster crystallization than other glycolide/lactide copolymers, and permits improved processing (faster crystallizing time, higher modulus, and increased degradation profile). Our Max-Prene® 955 polymer typically exhibits strength loss in one to four weeks with complete mass loss occurring in approximately six (6) months (depending on processing format and anatomical location). The Max-Prene® 955 polymer can be processed for a variety of applications, including extruded articles, fiber extrusion (e.g., suture such as Vicryl®), textiles, molded applications, and 3D Printing.
Beyond Max-Prene® 955, Poly-Med offers its Dioxaprene® 100M (PDO linear homopolymer) that can also be processed into a variety of formats similar to applications listed above. Dioxaprene® 100M polymer has a lower initial modulus compared to Max-Prene® 955 and is best utilized for applications looking for extended strength retention, coupled with increased flexibility. PDO based-polymers, (e.g., PDS® II sutures), maintain strength for 4 – 6 weeks with complete mass loss occurring in approximately nine (9) months (depending on processing format and anatomical location).
When selecting a polymer to best fit your device’s need, consider one of the two workhorse polymers (Max-Prene® 955 or Dioxaprene® 100M), which continues to drive innovation in the bioresorbable medical device industry and contact us today to learn more!